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Genetic pleiotropy underlying obesity and autoimmune disorders: a large-scale cross-trait gwas analysis in European ancestry populations

Abstract Background Obesity and autoimmune disorders represent a significant comorbidity burden, yet their shared genetic architecture is not fully understood. Elucidating the pleiotropic genetic basis underlying both conditions is crucial for unraveling the mechanisms driving their co-occurrence an...

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Autors principals: Xin Jiang, Shunqing Li, Shimao Zhang, Juntong Li, Deliang Liu, Hengxia Zhao
Format: Artigo
Idioma:Inglês
Publicat: BMC 2025-12-01
Col·lecció:Journal of Translational Medicine
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Accés en línia:https://doi.org/10.1186/s12967-025-07422-1
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