Continuous sensing of nutrients and growth factors by the mTORC1-TFEB axis

mTORC1 senses nutrients and growth factors and phosphorylates downstream targets, including the transcription factor TFEB, to coordinate metabolic supply and demand. These functions position mTORC1 as a central controller of cellular homeostasis, but the behavior of this system in individual cells h...

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Autors principals:	Breanne Sparta, Nont Kosaisawe, Michael Pargett, Madhura Patankar, Nicholaus DeCuzzi, John G Albeck
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2023-09-01
Col·lecció:	eLife
Matèries:	target of rapamycin (mTOR) cellular metabolism nutrient sensing glycogen synthase kinase 3 (GSK3) AKT AMP-activated protein kinase (AMPK)
Accés en línia:	https://elifesciences.org/articles/74903
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