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Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription

Summary: Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and FSS offers a crosstalk level to explain changes in SM...

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Principais autores: Jerome Jatzlau, Paul-Lennard Mendez, Aybuge Altay, Lion Raaz, Yufei Zhang, Sophia Mähr, Akin Sesver, Maria Reichenbach, Stefan Mundlos, Martin Vingron, Petra Knaus
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-09-01
Serier:iScience
Fag:
Biological sciences
Molecular biology
Molecular interaction
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589004223014827
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