A VP1 mutation acquired during an enterovirus 71 disseminated infection confers heparan sulfate binding ability and modulates ex vivo tropism.

Enterovirus 71 (EV71) causes hand, foot and mouth disease, a mild and self-limited illness that is sometimes associated with severe neurological complications. EV71 neurotropic determinants remain ill-defined to date. We previously identified a mutation in the VP1 capsid protein (L97R) that was acqu...

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Principais autores:	Eirini D Tseligka, Komla Sobo, Luc Stoppini, Valeria Cagno, Fabien Abdul, Isabelle Piuz, Pascal Meylan, Song Huang, Samuel Constant, Caroline Tapparel
Formato:	Artigo
Idioma:	Inglês
Publicado:	Public Library of Science (PLoS) 2018-08-01
Series:	PLoS Pathogens
Acceso en liña:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1007190&type=printable
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