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Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice

Human SNCA, which encodes a-synuclein protein (SNCA), was the first gene linked to familial Parkinson’s disease (PD). Since the discovery of the genetic link of SNCA to Parkinson’s nearly three decades ago, many studies have investigated the normal function of SNCA protein. However, understanding of...

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Principais autores: MegAnne Casey, Dan Zou, Renee A. Reijo Pera, Tiffany Hensley-McBain, Deborah E. Cabin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-07-01
coleção:Frontiers in Neuroscience
Assuntos:
Parkinson’s disease
Menkes disease
Atp7a
neurodegeneration
ENU mutagenesis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fnins.2025.1613171/full
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