Prognostic value of MGMT gene promoter methylation status in glioblastoma: A prospective study of patients treated with radiotherapy and temozolomide

Background: Glioblastoma (GBM) is the most aggressive primary brain tumor. O6-methylguanine-deoxyribonucleic acid-methyltransferase (MGMT) mediates resistance to temozolomide (TMZ). Epigenetic silencing of the MGMT gene promoter by hypermethylation has been proposed as a prognostic and predictive bi...

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Autori principali:	Tushar Marbate, Sourabh Zambre, Reshama Kailuke, Rohini Chaudhari, Mayur Ingle
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Manipal College of Medical Sciences, Pokhara 2026-07-01
Serie:	Asian Journal of Medical Sciences
Soggetti:	glioblastoma; o6-methylguanine-deoxyribonucleic acid-methyltransferase promoter methylation; temozolomide; stupp protocol; methylation-specific polymerase chain reaction; prognostic biomarker; overall survival; neuro-oncology
Accesso online:	https://ajmsjournal.info/index.php/AJMS/article/view/5401
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