Tumor-Associated Extracellular Matrix Obstacles for CAR-T Cell Therapy: Approaches to Overcoming

Chimeric antigen receptor (CAR)-T cell therapy yields good results in the treatment of various hematologic malignancies. However, the efficacy of CAR-T cell therapy against solid tumors has proven to be limited, primarily because the tumor-associated extracellular matrix (ECM) creates an intractable...

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Autors principals:	Ilya Klabukov, Alexander E. Kabakov, Anna Yakimova, Denis Baranovskii, Dmitry Sosin, Dmitry Atiakshin, Michael Ignatyuk, Elena Yatsenko, Victoria Rybachuk, Ekaterina Evstratova, Daria Eygel, Dmitry Kudlay, Vasiliy Stepanenko, Peter Shegay, Andrey D. Kaprin
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-01-01
Col·lecció:	Current Oncology
Matèries:	basement membrane cancer chimeric antigen receptor CAR-T cell therapy extracellular matrix fibrosis
Accés en línia:	https://www.mdpi.com/1718-7729/32/2/79
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