Genotoxic stress triggers Scd6-dependent regulation of translation to modulate the DNA damage response

Abstract The role of mRNA translation and decay in the genotoxic stress response remains poorly explored. Here, we identify the role of yeast RGG motif-containing RNA binding protein Scd6 and its human ortholog LSM14A in genotoxic stress response. Scd6 localizes to cytoplasmic puncta upon cell treat...

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Autors principals:	Gayatri Mohanan, Raju Roy, Hélène Malka-Mahieu, Swati Lamba, Lucilla Fabbri, Sidhant Kalia, Anusmita Biswas, Sylvain Martineau, Céline M Labbé, Stéphan Vagner, Purusharth I Rajyaguru
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2025-04-01
Col·lecció:	EMBO Reports
Matèries:	DNA Damage Genotoxic Stress mRNA Translation RNA Binding Protein RNA Granules
Accés en línia:	https://doi.org/10.1038/s44319-025-00443-3
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