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OPRM1/MRGPRX1 heterodimers drive opioid-induced itch through a peripheral mechanism

Abstract Background Opioid-induced itch is a common and distressing side effect of opioid analgesics, yet its underlying mechanisms remain poorly understood. While central µ-opioid receptor (OPRM1) signaling has been implicated, emerging evidence suggests that peripheral mechanisms also contribute,...

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Principais autores: Babina Sanjel, Diwas Rawal, Myeong Ryeo Kim, Wook-Joo Lee, Kwang Won Jeong, Won-Sik Shim
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Biomedical Science
Fag:
Opioid
Heterodimer
OPRM1
MRGPRX1
Pruritus
Peripheral sensory neuron
Online adgang:https://doi.org/10.1186/s12929-026-01238-x
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