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HOXB8 enhances the proliferation and metastasis of colorectal cancer cells by promoting EMT via STAT3 activation

Abstract Background Previous studies have demonstrated that the expression of homeobox8 (HOXB8) is higher in colorectal cancer (CRC) tissues than in normal tissues; however, the precise role of HOXB8 in human CRC cells remains to be elucidated. Methods We generated lentiviral constructs to overexpre...

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Автори: Tingting Wang, Feiyan Lin, Xuecheng Sun, Lei Jiang, Ruibo Mao, Shenyue Zhou, Wenjing Shang, Ruichun Bi, Fengying Lu, Shaotang Li
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2019-01-01
Серія:Cancer Cell International
Предмети:
Colorectal cancer
Epithelial–mesenchymal transition
HOXB8
Signal transducer and activator of transcription 3
Онлайн доступ:http://link.springer.com/article/10.1186/s12935-018-0717-6
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