NAMPT inhibition induces ferroptosis via mitochondrial metabolic reprogramming to enhance tumour immunogenicity in glioblastoma

BackgroundFerroptosis has recently been recognised as an immunogenic form of regulated cell death. Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme in the NAD+ salvage pathway, is highly expressed in glioblastoma and represents a promising metabolic target.MethodsWe investigated the effe...

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主要な著者:	Dongxu Zhao, Lin Duan, Hang Ren, Hang Zhang, Menghui Zhang, Zhuohang Liu, Hailan Wang, Wenxuan Lu, Wenhan Shi, Qingwang Hou, Tianxiao Li, Ming Li
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2026-03-01
シリーズ:	Frontiers in Immunology
主題:	ferroptosis glioblastoma immunogenicity mitochondrial metabolic reprogramming NAMPT inhibitor
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1721125/full
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