Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma

Summary: Li-Fraumeni syndrome (LFS) is characterized by constitutional pathogenic TP53 mutation and increased risk of cancer development, including Sonic Hedgehog-activated medulloblastoma (SHH-MB). In LFS patients, radiation and DNA-damaging agents can exhibit lower efficiency and cause secondary m...

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Hauptverfasser:	Anna S. Kolodziejczak, Florian Selt, Heike Peterziel, Nora Jamaladdin, Norman Mack, Kendra Maaß, Chris Meulenbroeks, Romain Sigaud, Christel Herold-Mende, Ahmed El Damaty, Jürgen Burhenne, Shunya Ohmura, Tim Holland-Letz, Lena M. Kutscher, Aurélie Ernst, Pei-Chi Wei, Thomas G.P. Grünewald, Ina Oehme, Marcel Kool, David T.W. Jones, Kristian W. Pajtler, Christian P. Kratz, Stefan M. Pfister, Olaf Witt, Till Milde
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2026-02-01
Schriftenreihe:	iScience
Schlagworte:	Biological sciences Cancer systems biology Natural sciences Pharmacology Systems biology
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004225028251
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