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ARID1A Governs Genomic Stability and Proliferation in SCLC via c-MYC/PARP1 Suppression Driving Vulnerability to BET Inhibitors

Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor among the most lethal cancers. ARID1A has a dual role in oncogenic and tumor-suppressive functions, depending on the type of cancer. However, its role in SCLC remains unclear. Herein, we showed that ARID1A was highly expressed...

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Detalhes bibliográficos
Principais autores: Guozhen Cao, Liying Ma, Xueqin Dai, Peng Hou, Xinhuang Yao, Gongfeng Li, Jiahui Zhang, Ceshi Chen, Wenchu Lin
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science (AAAS) 2025-01-01
coleção:Research
Acesso em linha:https://spj.science.org/doi/10.34133/research.0908
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