Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis

Abstract Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2 regulate craniofacial morphogenesis and their disruption result in OFC in zebrafish, mouse and humans. Using esrp1/2 mutant zebrafish and murine Py2T cell line models, we...

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Detalhes bibliográficos

Principais autores:	Caroline Caetano da Silva, Claudio Macias Trevino, Jason Mitchell, Hemma Murali, Casey Tsimbal, Eileen Dalessandro, Shannon H. Carroll, Simren Kochhar, Sarah W. Curtis, Ching Hsun Eric Cheng, Feng Wang, Eric Kutschera, Russ P. Carstens, Yi Xing, Kai Wang, Elizabeth J. Leslie, Eric C. Liao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-08-01
coleção:	Communications Biology
Acesso em linha:	https://doi.org/10.1038/s42003-024-06715-3
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