Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment

Multiple findings underline a link between altered brain cholesterol metabolism and Alzheimer's disease (AD) pathogenesis. Physiologically, excess brain cholesterol is mainly converted into 24-hydroxycholesterol (24-OHC) by the neuron-specific enzyme CYP46A1. Of note, we previously observed in autop...

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Principais autores:	Serena Giannelli, Francesca Eroli, Raúl Loera-Valencia, Valerio Leoni, Maria Latorre-Leal, Gabriella Testa, Erica Staurenghi, Barbara Sottero, Paola Gamba, Silvia Maioli, Gabriella Leonarduzzi
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2025-10-01
叢編:	Neurobiology of Disease
主題:	24-hydroxycholesterol CYP46A1 Tau hyperphosphorylation Tau oligomers Dendritic arborization Alzheimer's disease
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S0969996125002451
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