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Genome-wide CRISPR screen identified a role for commander complex mediated ITGB1 recycling in basal insulin secretion

Objectives: Pancreatic beta cells secrete insulin postprandially and during fasting to maintain glucose homeostasis. Although glucose-stimulated insulin secretion (GSIS) has been extensively studied, much less is known about basal insulin secretion. Here, we performed a genome-wide CRISPR/Cas9 knock...

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Principais autores: Liu Yang, Margret A. Fye, Bingyuan Yang, Zihan Tang, Yue Zhang, Sander Haigh, Brittney A. Covington, Kai Bracey, Justin W. Taraska, Irina Kaverina, Shen Qu, Wenbiao Chen
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-09-01
Serier:Molecular Metabolism
Fag:
Commander
Integrin beta1
CRISPR screen
Insulin secretion
Endosomal recycling
Focal adhesions
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877822001107
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