Synergistic induction of autophagy in gastric cancer by targeting CDK4/6 and MEK through AMPK/mTOR pathway

KRAS is a commonly mutated oncogene in human gastric cancer and is often associated with drug resistance and poor prognosis. Co-clinical trial of combined MEK-CDK4/6 inhibition in KRAS mutated cancers demonstrated therapeutic efficacy in patient-derived xenografts and safety in patients. Here, prese...

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Үндсэн зохиолчид:	Hong Zhou, Guiling Li, Liuyue Kan, Mingyu Yang, Yu Liu, Xiaye Miu, Lei Shi, Zhanjun Yang, Xucai Zheng, Hui Chen, Chuanli Ren
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2024-05-01
Цуврал:	Heliyon
Нөхцлүүд:	Gastric cancer KRAS MEK CDK4/6 AMPK/mTOR
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S240584402406506X
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!