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SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1

Abstract Folliculogenesis is a crucial process for production functional female gametes in mammals. The imbalance of apoptosis and proliferation of ovarian granulosa cells has been identified as an important cause for abnormal folliculogenesis. Sex-determining region Y-box protein 3 (SOX3), belonged...

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Principais autores: Rui Cai, Cong Li, Wenhui Shi, Fenfen Xie, Mengmeng Fan, Hao Zhang, Zhuang Liu, Yuanhua Chen, Qiang Hong
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2025-06-01
Serier:Cellular and Molecular Life Sciences
Fag:
Folliculogenesis
SOX3
Proliferation
Apoptosis
SPP1
PI3K/AKT pathway
Online adgang:https://doi.org/10.1007/s00018-025-05797-4
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