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SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation

Abstract Many essential proteins require pyridoxal 5’-phosphate, the active form of vitamin B6, as a cofactor for their activity. These include enzymes important for amino acid metabolism, one-carbon metabolism, polyamine synthesis, erythropoiesis, and neurotransmitter metabolism. A third of all mam...

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I tiakina i:
Ngā kaituhi matua: Izabella A. Pena, Jeffrey S. Shi, Sarah M. Chang, Jason Yang, Samuel Block, Charles H. Adelmann, Heather R. Keys, Preston Ge, Shveta Bathla, Isabella H. Witham, Grzegorz Sienski, Angus C. Nairn, David M. Sabatini, Caroline A. Lewis, Nora Kory, Matthew G. Vander Heiden, Myriam Heiman
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2025-01-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-025-56130-3
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