Intra- and inter-tumoural heterogeneity in von Hippel–Lindau disease-related renal cancer: a multimodal data study protocol

Abstract von Hippel–Lindau (VHL) disease is a rare hereditary cancer syndrome caused by germline pathogenic variants in the VHL gene. The current standard of care primarily involves surgical resection, which is arbitrarily recommended for renal tumours ≥ 3 cm to reduce the risk of metastasis. Howeve...

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Principais autores:	Isaline Rowe, Alberto Colombo, Francesca Corea, Francesco Pisu, Francesca Genova, Martina Uggé, Chiara Ciaparrone, Antonino Giangrasso, Giovanni B. Pipitone, Giulia M. Scotti, Alessandro Larcher, Giorgia Colciago, Marco J. Morelli, Roberta Lucianò, Paola Carrera, Pio Zeppa, Alessandro Caputo, Roberto Bertini, Francesco Montorsi, Andrea Salonia, Paolo Verze, Anna Palmisano, Antonio Esposito, Rosa Bernardi, Umberto Capitanio
Formato:	Artigo
Idioma:	Inglês
Publicado:	SpringerOpen 2025-11-01
Series:	European Radiology Experimental
Assuntos:	Carcinoma (renal cell) Magnetic resonance imaging Multiomics Organoids von Hippel–Lindau disease
Acceso en liña:	https://doi.org/10.1186/s41747-025-00648-0
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