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Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal Cancer

Summary: Growing evidence indicates a role for the gut microbiota in modulating anti-tumor treatment efficacy in human cancer. Here we study mucosa-associated invariant T (MAIT) cells to look for evidence of bacterial antigen recognition in human colon, lung, and kidney carcinomas. Using mass cytome...

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Autori principali: Shamin Li, Yannick Simoni, Etienne Becht, Chiew Yee Loh, Naisi Li, Daniel Lachance, Si-Lin Koo, Teck Por Lim, Emile Kwong Wei Tan, Ronnie Mathew, Andrew Nguyen, Justin Golovato, Julia D. Berkson, Martin Prlic, Bernett Lee, Samuel S. Minot, Niranjan Nagarajan, Neelendu Dey, Daniel S.W. Tan, Iain B. Tan, Evan W. Newell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020-06-01
Serie:Cell Reports Medicine
Soggetti:
MAIT
colorectal cancer
CD39
microbiome
CyTOF
Accesso online:http://www.sciencedirect.com/science/article/pii/S2666379120300513
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