Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis. Here, using [11C]UCB-J PET, the authors show for the first time in vivo that levels of the synaptic marker protein SV2A are reduced in schizophrenia and unaffected by antipsychotic treatment in a rat model.

מידע ביבליוגרפי

Principais autores:	Ellis Chika Onwordi, Els F. Halff, Thomas Whitehurst, Ayla Mansur, Marie-Caroline Cotel, Lisa Wells, Hannah Creeney, David Bonsall, Maria Rogdaki, Ekaterina Shatalina, Tiago Reis Marques, Eugenii A. Rabiner, Roger N. Gunn, Sridhar Natesan, Anthony C. Vernon, Oliver D. Howes
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Portfolio 2020-01-01
סדרה:	Nature Communications
גישה מקוונת:	https://doi.org/10.1038/s41467-019-14122-0
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!