IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

Abstract Background Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus o...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Fátima Rivera-Escalera, Jonathan J. Pinney, Laura Owlett, Hoda Ahmed, Juilee Thakar, John A. Olschowka, Michael R. Elliott, M. Kerry O’Banion
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-12-01
coleção:	Journal of Neuroinflammation
Assuntos:	Alzheimer’s disease Interleukin-1β Neuroinflammation Microglia Phagocytosis Amyloid plaque
Acesso em linha:	https://doi.org/10.1186/s12974-019-1645-7
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!