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Failure to rescue the trial: lessons from a randomised antibiotic treatment trial in the acute care setting

Abstract Background A cluster-randomised cross-over trial assessing whether cephalosporin monotherapy is non-inferior to cefuroxime plus short-course aminoglycoside combination therapy for empirical sepsis treatment was terminated for operational futility due to low enrolment and low protocol adhere...

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Principais autores: Sharon E. J. D. van den Eijnde, Eva L. Koekenbier, Paul D. van der Linden, Jan Jelrik Oosterheert, Marc J. M. Bonten, Cornelis H. van Werkhoven, on behalf of the SAGA study group
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Trials
Fag:
Clinical trial
Sepsis
Aminoglycoside
Barriers
Antibiotics
Online adgang:https://doi.org/10.1186/s13063-026-09722-3
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