Ets-2 Acts As a Transcriptional Repressor of the Human Immunodeficiency Virus Type 1 through Binding to a Repressor–Activator Target Sequence of 5′-LTR

HIV-1 is transcriptionally active in activated T helper (Th)-cells and inactive in naive or resting memory Th-cells. Ets-2 is a preinduction transcriptional repressor of the IL-2 gene in naive Th-cells and a candidate transcriptional repressor of HIV-1 in the same cells, because the −279 to −250 ups...

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Principais autores:	Ioannis Panagoulias, Fotios Karagiannis, Ioanna Aggeletopoulou, Tassos Georgakopoulos, Christos P. Argyropoulos, Karolina Akinosoglou, Charalambos Gogos, Athanasios Skoutelis, Athanasia Mouzaki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-01-01
coleção:	Frontiers in Immunology
Assuntos:	HIV-1 Ets-2 repressor–activator target sequence transcription factors repressor T helper cells
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01924/full
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