Glutamate receptor–T cell receptor signaling potentiates full CD8+ T cell activation and effector function in tumor immunity

Summary: Glutamate is best known as an excitatory neurotransmitter. However, its roles in T cell immunity remain underrecognized. We investigated the interplay between glutamate receptors (GluRs) and T cell receptors (TCRs) during CD8+ T cell activation. Our findings reveal that GluR expression in C...

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Autores principales: Maria Teresa P. de Aquino, Thomas W. Hodo, Salvador González Ochoa, Roman V. Uzhachenko, Muna A. Mohammed, J. Shawn Goodwin, Thanigaivelan Kanagasabai, Alla V. Ivanova, Anil Shanker
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2025-10-01
Colección:iScience
Materias:
immune response
immunology
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S2589004225010338
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