Prolyl hydroxylase domain enzyme PHD2 inhibits proliferation and metabolism in non-small cell lung cancer cells in HIF-dependent and HIF-independent manners

Prolyl hydroxylase domain protein 2 (PHD2) is one of the intracellular oxygen sensors that mediates proteasomal degradation of hypoxia-inducible factor (HIF)-α via hydroxylation under normoxic conditions. Because of its canonical function in the hypoxia signaling pathway, PHD2 is generally regarded...

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Principais autores:	Hongyan Deng, Zixuan Wang, Chunchun Zhu, Zhu Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-06-01
Colecção:	Frontiers in Oncology
Assuntos:	PHD2 prolyl hydroxylase non-small cell lung cancer HIF-dependent HIF-independent
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1370393/full
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