Somatic Mosaicism of IDH1 R132H Predisposes to Anaplastic Astrocytoma: A Case of Two Siblings

Anaplastic astrocytomas are aggressive glial cancers that present poor prognosis and high recurrence. Heterozygous IDH1 R132H mutations are common in adolescent and young adult anaplastic astrocytomas. In a majority of cases, the IDH1 R132H mutation is unique to the tumor, although rare cases of ana...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Sulgi Lee, Madhuri Kambhampati, M. Isabel Almira-Suarez, Cheng-Ying Ho, Eshini Panditharatna, Seth I. Berger, Joyce Turner, David Van Mater, Lindsay Kilburn, Roger J. Packer, John S. Myseros, Eric Vilain, Javad Nazarian, Miriam Bornhorst
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-01-01
coleção:	Frontiers in Oncology
Assuntos:	anaplastic astrocytoma mosaicism cancer predisposition ddPCR AYA (adolescents and young adults) IDH1 R132H mutation
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fonc.2019.01507/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!