A Detailed View of KIR Haplotype Structures and Gene Families as Provided by a New Motif-Based Multiple Sequence Alignment

Human chromosome 19q13.4 contains genes encoding killer-cell immunoglobulin-like receptors (KIR). Reported haplotype lengths range from 67 to 269 kb and contain 4 to 18 genes. The region has certain properties such as single nucleotide variation, structural variation, homology, and repetitive elemen...

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Bibliografische Detailangaben

Hauptverfasser:	David Roe, Cynthia Vierra-Green, Chul-Woo Pyo, Daniel E. Geraghty, Stephen R. Spellman, Martin Maiers, Rui Kuang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-11-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	killer-cell immunoglobulin-like receptors (KIR) alignment DNA haplotype nomenclature natural killer
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.585731/full
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