Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer’s Disease

Neuroinflammation driven by the accumulation of amyloid β (Aβ) can lead to neurofibrillary tangle formation in Alzheimer’s Disease (AD). To test the hypothesis that an anti-inflammatory immunomodulatory agent might have beneficial effects on amyloid and tau pathology, as well as microglial phenotype...

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Hlavní autoři:	Dawling A. Dionisio-Santos, Berke Karaahmet, Elizabeth K. Belcher, Laura D. Owlett, Lee A. Trojanczyk, John A. Olschowka, M. Kerry O’Banion
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-10-01
Edice:	Frontiers in Neuroscience
Témata:	Alzheimer’s disease beta amyloid tau phosphorylation neuroinflammation microglia glatiramer acetate
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnins.2021.758677/full
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