Lack of telomerase reduces cancer incidence and increases lifespan of zebrafish tp53 M214K mutants
Abstract Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence. These processes reduce cell proliferation and...
Zapisane w:
| Główni autorzy: | , , |
|---|---|
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Portfolio
2024-03-01
|
| Seria: | Scientific Reports |
| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1038/s41598-024-56153-8 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
|