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One gene to rule them all – clinical perspectives of a potent suppressor of cytokine signaling – SOCS1

The discovery of Suppressor of Cytokine Signaling 1 (SOCS1) in 1997 marked a significant milestone in understanding the regulation of Janus kinase/Signal transducer and activator of transcription (JAK/STAT) signaling pathways. Subsequent research deciphered its cellular functions, and recent insight...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Julia Körholz, Lan-Sun Chen, Timmy Strauss, Catharina Schuetz, Alexander H. Dalpke
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2024-04-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
SOCS1
SOCS1-HI
JAKinhibitors
SOCS1-immunity
multisystem immune dysregulation
monogenic hyperinflammation
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1385190/full
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