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Multi-Modal Biomarker Profiling of Tumor Microenvironment and Genomic Alterations to Enhance Immunotherapy Stratification in Melanoma

Tumor mutational burden (TMB) and tumor-infiltrating lymphocytes (TILs) are key biomarkers for predicting immunotherapy responses in cutaneous melanoma. The discordance between brisk TIL morphology and absent cytokine signals complicates immune profiling. We examined the interactions between TMB, TI...

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Principais autores: Meshack Bida, Thabiso Victor Miya, Tebogo Marutha, Rodney Hull, Mohammed Alaouna, Zodwa Dlamini
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-10-01
coleção:Current Issues in Molecular Biology
Assuntos:
cutaneous melanoma
tumor mutational burden
tumor-infiltrating lymphocytes
cytokine signaling
immune escape
genomic profiling
Acesso em linha:https://www.mdpi.com/1467-3045/47/10/821
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