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Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

Enterovirus A71 (EV-A71) infection is a major cause of hand, foot, and mouth disease (HFMD), which may be occasionally associated with severe neurological complications. There is currently a lack of treatment options for EV-A71 infection. The Raf-MEK-ERK signaling pathway, in addition to its critica...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Bodan Hu, Kenn Ka-Heng Chik, Jasper Fuk-Woo Chan, Jian-Piao Cai, Hehe Cao, Jessica Oi-Ling Tsang, Zijiao Zou, Yin-Po Hung, Kaiming Tang, Lilong Jia, Cuiting Luo, Feifei Yin, Zi-Wei Ye, Hin Chu, Man-Lung Yeung, Shuofeng Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-08-01
Schriftenreihe:Pharmaceuticals
Schlagworte:
enterovirus
vemurafenib
RAF
MAPK signaling pathway
genome replication
virus assembly
Online-Zugang:https://www.mdpi.com/1424-8247/15/9/1067
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