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Using NMR-detected hydrogen-deuterium exchange to quantify protein stability in cosolutes, under crowded conditions in vitro and in cells

We review the use of nuclear magnetic resonance (NMR) spectroscopy to assess the exchange of amide protons for deuterons (HDX) in efforts to understand how high concentration of cosolutes, especially macromolecules, affect the equilibrium thermodynamics of protein stability. HDX NMR is the only meth...

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Hoofdauteurs: I-Te Chu, Gary J. Pielak
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: KeAi Communications Co. Ltd. 2023-11-01
Reeks:Magnetic Resonance Letters
Onderwerpen:
Amide proton exchange
Cosolutes
Equilibrium thermodynamics
Macromolecular
Crowding
Osmolytes
Online toegang:http://www.sciencedirect.com/science/article/pii/S2772516223000256
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