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Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

Vulnerability to noise-induced tinnitus is associated with increased spontaneous firing rate in dorsal cochlear nucleus principal neurons, fusiform cells. This hyperactivity is caused, at least in part, by decreased Kv7.2/3 (KCNQ2/3) potassium currents. However, the biophysical mechanisms underlying...

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Principais autores: Shuang Li, Bopanna I Kalappa, Thanos Tzounopoulos
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2015-08-01
coleção:eLife
Assuntos:
potassium channel
HCN channels
tinnitus
homeostatic plasticity
hyperexcitability-related disorders
Acesso em linha:https://elifesciences.org/articles/07242
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