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Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes

IntroductionVestigial-like 1 (VGLL1) is a co-transcriptional activator that binds to TEA domain-containing transcription factors (TEADs). Its expression is upregulated in a variety of aggressive cancer types, including pancreatic and basal-like breast cancer, and increased transcription of VGLL1 is...

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Hoofdauteurs: Heather M. Sonnemann, Barbara Pazdrak, Barbara Nassif, Yimo Sun, Lama Elzohary, Amjad H. Talukder, Arjun S. Katailiha, Krishna Bhat, Gregory Lizée
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2024-06-01
Reeks:Frontiers in Oncology
Onderwerpen:
pancreatic cancer
breast cancer
migration and invasion
mechanism of tumor progression
mechanism of transcription
cell proliferation
Online toegang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1403052/full
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