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ATP-Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance and Is Depressed in Human Failing Myocardium

Summary: ATP-citrate lyase (ACLY) regulates lipogenesis and cell proliferation, and forms a cytosolic TCA-bypass circuit impacting NADH. We show that acute and chronic ACLY inhibition in cardiomyocytes depresses the NAD+/NADH ratio by increasing mitochondrial NADH. Acute suppression causes dose-depe...

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Principais autores: Mariam Meddeb, MD, Navid Koleini, MD, PhD, Mohammad Keykhaei, MD, Ting Liu, PhD, Marcus Rhodehamel, BA, Lorena Mandarano, BS, Farnaz Farshidfar, MD, Liang Zhao, PhD, Seoyoung Kwon, BS, Gizem Keceli, PhD, Ismayil Ahmet, PhD, Nazareno Paolocci, MD, PhD, Virginia Hahn, MD, Kavita Sharma, MD, Erika L. Pearce, PhD, David A. Kass, MD
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-07-01
Series:JACC: Basic to Translational Science
Assuntos:
heart disease
metabolism
myocardium
redox
reductive stress
TCA cycle
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2452302X25002219
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