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The Na+,K+,2Cl− Cotransporter, Not Aquaporin 1, Sustains Cerebrospinal Fluid Secretion While Controlling Brain K+ Homeostasis

Abstract Disturbances in the brain fluid balance can lead to life‐threatening elevation in intracranial pressure (ICP), which represents a vast clinical challenge. Targeted and efficient pharmaceutical therapy of elevated ICP is not currently available, as the molecular mechanisms governing cerebros...

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Principais autores: Dennis Bo Jensen, Trine L. Toft‐Bertelsen, Dagne Barbuskaite, Jane Stubbe, Sandor Nietzsche, Tenna Capion, Nicolas H. Norager, Markus H. Olsen, Andreas T. Sørensen, Henrik Dimke, Christian A. Hübner, Marianne Juhler, Nanna MacAulay
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-02-01
Serier:Advanced Science
Fag:
aquaporin
choroid plexus
CSF
hydrocephalus
K+
NKCC1
Online adgang:https://doi.org/10.1002/advs.202409120
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