Single-cell transcriptomics in bone marrow delineates CD56dimGranzymeK+ subset as intermediate stage in NK cell differentiation

Human natural killer (NK) cells in lymphoid tissues can be categorized into three subsets: CD56brightCD16+, CD56dimCD16+ and CD69+CXCR6+ lymphoid tissue-resident (lt)NK cells. How the three subsets are functionally and developmentally related is currently unknown. Therefore, we performed single-cell...

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主要な著者:	Janine E. Melsen, Monique M. van Ostaijen-ten Dam, Dorenda J. A. Schoorl, Pieter J. Schol, Daphne A. L. van den Homberg, Arjan C. Lankester, Gertjan Lugthart, Marco W. Schilham
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2022-11-01
シリーズ:	Frontiers in Immunology
主題:	spectral cytometry single-cell RNA sequencing natural killer cells (NK cells) bone marrow pseudotime analysis
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1044398/full
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