Spatial regulation of chrysosplenetin on amino acid homeostasis linked to artemisinin resistance in Plasmodium berghei K173 based on targeted metabolomics

Abstract Chrysosplenetin, a polymethoxy flavonol purified in our laboratory from the waste products generated during the industrial extraction of artemisinin, has been previously demonstrated to be a potential inhibitor of artemisinin resistance. Based on NMR-untargeted metabolomics, one of its hypo...

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Hauptverfasser:	Jinjing Xu, Hongyan Ji, Ying Yao, Xudong Liu, Yutao Huang, Yanqing Zhang, Yaqin Tang, Jing Chen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-04-01
Schriftenreihe:	Scientific Reports
Schlagworte:	LC-MS/MS based targeted metabolomics Artemisinin resistance Chrysosplenetin Amino acids TMAO
Online-Zugang:	https://doi.org/10.1038/s41598-025-98409-x
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