Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations

Because of high stability and slow unfolding rates of G-quadruplexes (G4), cells have evolved specialized helicases that disrupt these non-canonical DNA and RNA structures in an ATP-dependent manner. One example is DHX36, a DEAH-box helicase, which participates in gene expression and replication by...

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Hlavní autoři:	Kazi Amirul Hossain, Michal Jurkowski, Jacek Czub, Mateusz Kogut
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Association for the Advancement of Science (AAAS) 2021-01-01
Edice:	Computational and Structural Biotechnology Journal
Témata:	G-quadruplex RHAU helicase DHX36 DEAH-box family Molecular dynamics Free energy simulation
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2001037021001513
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