Microbiota-mediated skewing of tryptophan catabolism modulates CD4+ T cells in lupus-prone mice

Summary: A skewed tryptophan metabolism has been reported in patients with lupus. Here, we investigated the mechanisms by which it occurs in lupus-susceptible mice, and how tryptophan metabolites exacerbate T cell activation. Metabolomic analyses demonstrated that tryptophan is differentially catabo...

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Detalhes bibliográficos

Principais autores:	Josephine Brown, Georges Abboud, Longhuan Ma, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Jean Lee, Weidan Peng, Joy Cagmat, Tamas Faludi, Mansour Mohamadzadeh, Timothy Garrett, Laura Mandik-Nayak, Alexander Chervonsky, Andras Perl, Laurence Morel
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-05-01
coleção:	iScience
Assuntos:	Biological sciences Human metabolism Immunology Cell biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004222005119
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