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Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Background. Glucocorticoid excess has been linked to clinical observations associated with the pathophysiology of metabolic syndrome. The intracellular glucocorticoid levels are primarily modulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme that is highly expressed in key metabolic...

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Auteurs principaux: Thirumurugan Rathinasabapathy, Kimberly Marie Palatini Jackson, Yiwen Thor, Ayuba Sunday Buru, Debora Esposito, Xu Li, Mallikarjuna Rao Pichika, Ahmad Sazali Hamzah, Slavko Komarnytsky
Format: Artigo
Langue:Inglês
Publié: Wiley 2017-01-01
Collection:Journal of Chemistry
Accès en ligne:http://dx.doi.org/10.1155/2017/3182129
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