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Osteocytes in the Metastatic Bone Niche: Mechanistic Pathways and Therapeutic Targets

Osteocytes, once viewed mainly as passive bone-embedded cells, are now recognized as active regulators of the metastatic bone niche. Emerging evidence indicates that these cells integrate mechanical, inflammatory, and tumor-derived cues to influence metastatic seeding, dormancy, reactivation, and le...

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Autori principali: Alhomam Dabaliz, Mohamad Bakir, Lana Fatash, Mais Aldoush, Khalid Said Mohammad
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2026-04-01
Serie:Pharmaceuticals
Soggetti:
osteocytes
bone metastasis
metastatic niche
mechanotransduction
sclerostin (SOST)
targeted therapy
Accesso online:https://www.mdpi.com/1424-8247/19/4/644
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