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Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease

Neuroinflammation is a key component of Alzheimer's disease (AD) pathogenesis. Particularly, the proinflammatory cytokine interleukin-1 beta (IL-1β) is upregulated in human AD and believed to promote amyloid plaque deposition. However, studies from our laboratory have shown that chronic IL-1β overex...

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Main Authors: Fátima Rivera-Escalera, Sarah B. Matousek, Simantini Ghosh, John A. Olschowka, M. Kerry O’Banion
Format: Artigo
Language:Inglês
Published: Elsevier 2014-09-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
CCR2
Interleukin-1β
Neuroinflammation
Monocytes
Bone marrow derived
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001363
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