Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics
Antibody formation to human(ized) therapeutic antibodies in humans is highly skewed toward anti-idiotype responses, probably because the idiotype is the only ‘foreign’ part of the antibody molecule. Here, we analyzed antibody responses to F(ab’)2 fragments of a panel of 17 human(ized) therapeutic an...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis Group
2020-01-01
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| coleção: | mAbs |
| Assuntos: | |
| Acesso em linha: | https://www.tandfonline.com/doi/10.1080/19420862.2020.1814661 |
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