Microenvironmental stiffness induces metabolic reprogramming in glioblastoma

Summary: The mechanical properties of solid tumors influence tumor cell phenotype and the ability to invade surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids, this study demonstrates that a soft, brain-like matrix...

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Principais autores:	Alireza Sohrabi, Austin E.Y.T. Lefebvre, Mollie J. Harrison, Michael C. Condro, Talia M. Sanazzaro, Gevick Safarians, Itay Solomon, Soniya Bastola, Shadi Kordbacheh, Nadia Toh, Harley I. Kornblum, Michelle A. Digman, Stephanie K. Seidlits
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2023-10-01
叢編:	Cell Reports
主題:	CP: Cancer CP: Metabolism
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2211124723011877
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