Biodistribution and dosimetry of the GluN2B-specific NMDA receptor PET radioligand (R)-[11C]Me-NB1

Abstract Background The NMDA receptor (NMDAR) plays a key role in the central nervous system, e.g., for synaptic transmission. While synaptic NMDARs are thought to have protective characteristics, activation of extrasynaptic NMDARs might trigger excitotoxic processes linked to neuropsychiatric disor...

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Principais autores:	Lucas Rischka, Matej Murgaš, Verena Pichler, Chrysoula Vraka, Ivo Rausch, Dietmar Winkler, Lukas Nics, Sazan Rasul, Leo Robert Silberbauer, Murray Bruce Reed, Godber Mathis Godbersen, Jakob Unterholzner, Patricia Handschuh, Gregor Gryglewski, Thomas Mindt, Markus Mitterhauser, Andreas Hahn, Simon Mensah Ametamey, Wolfgang Wadsak, Rupert Lanzenberger, Marcus Hacker
格式:	Artigo
语言:	Inglês
出版:	SpringerOpen 2022-08-01
丛编:	EJNMMI Research
主题:	GluN2B-subunit NMDA receptor PET Dosimetry Biodistribution Neuropsychiatric disorders
在线阅读:	https://doi.org/10.1186/s13550-022-00925-8
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