Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions
A novel flow-based approach for the preparation of benzimidazol-2-one (<b>1</b>) scaffold by the 1,1′-carbonyldiimidazole (CDI)-promoted cyclocarbonylation of <i>o</i>-phenylenediamine (<b>2</b>) is reported. Starting from a preliminary batch screening, the model reaction was successfully tran...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2019-07-01
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| coleção: | Molecules |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1420-3049/24/13/2447 |
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